Description

The liver is one of the body’s primary centers of metabolic integration and plays an active role in maintaining homeostasis through processes related to energy metabolism, the synthesis and storage of molecules, bile production, the biotransformation of substances, immune responses, and communication with other organs and tissues. This book provides a comprehensive overview of liver health, integrating anatomical, physiological, metabolic, and clinical foundations with the principal mechanisms involved in the development and progression of hepatobiliary diseases. It examines the regulation of bile acids and the gut-liver axis, regenerative capacity, steatotic liver disease, alcohol-associated liver injury, viral hepatitis, cirrhosis, and its complications. It also explores the influence of refined sugars, processed fats, medications, everyday toxic substances, and environmental exposures on hepatocellular function. The book further incorporates contemporary perspectives related to the gut microbiota, circadian rhythms, chrononutrition, time-restricted eating, physical exercise, emerging biomarkers, and non-invasive monitoring methods. Particular emphasis is placed on distinguishing scientific evidence from popular claims concerning detoxification, supplements, and nutritional strategies. From an integrative perspective, the book connects pathophysiological mechanisms, modifiable factors, prevention, risk assessment, and clinical decision-making. It proposes understanding the liver not as an isolated organ, but as a dynamic component of a systemic network whose stability is essential for maintaining metabolic balance and human health.

Suggested citation (APA, seventh edition)

Gomez-Rutti, Y. Y., Gordillo-Cortaza, J. D. R., & Inocente-Camones, M. A. (Eds.). (2026). Hígado y homeostasis: El eje del metabolismo. Sophia Editions.